Beryllium Disease Article

Detection of beryllium distinguishes the granulomas of chronic beryllium disease from other diseases, in particular sarcoidosis. The role of beryllium lymphocyte transformation tests is discussed. Chronic beryllium disease is steroid dependent and local excision of skin lesions appears to be curative.

Berylliosis, or chronic beryllium disease (CBD), is a chronic allergic-type lung response and chronic lung disease caused by exposure to beryllium and its compounds, a form of beryllium poisoning. It is distinct from acute beryllium poisoning, which became rare following occupational exposure limits established around 1950. Berylliosis is an occupational lung disease. While there is no cure, symptoms can be treated.

@article{osti_5596744, title = {Beryllium disease}, author = {}, abstractNote = {After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe.

17-10-2020· Acute beryllium disease is a chemical pneumonitis causing diffuse parenchymal inflammatory infiltrates and nonspecific intra-alveolar edema. Other tissues (eg, skin, conjunctivae) may be affected. Acute beryllium disease is now rare because most industries have reduced exposure levels, but cases were common between 1940 and 1970, and many cases progressed from acute to chronic beryllium disease.

Beryllium disease. Necessity for continuing surveillance. Chest. 1983 Sep; 84 (3):312–312. Williams WJ. Beryllium disease--pathology and diagnosis. J Soc Occup Med. 1977 Jul; 27 (3):93–96. Sprince NL, Kazemi H, Hardy HL. Current (1975) problem of differentiating between beryllium disease and sarcoidosis. Ann N Y Acad Sci. 1976; 278:654–664.

Acute beryllium disease is very rare today. Current workplace safety regulations prevent the massive quantities of beryllium that cause acute beryllium disease from being released into the air. Chronic beryllium disease (CBD, berylliosis) is associated with inhaling beryllium powder or fumes (although inhaling beryllium does not always lead to CBD).

17-10-2020· Acute beryllium disease is a chemical pneumonitis causing diffuse parenchymal inflammatory infiltrates and nonspecific intra-alveolar edema. Other tissues (eg, skin, conjunctivae) may be affected. Acute beryllium disease is now rare because most industries have reduced exposure levels, but cases were common between 1940 and 1970, and many cases progressed from acute to chronic beryllium disease.

15-10-2012· Chronic beryllium disease (CBD) is an immunologic lung disease caused by inhalation of beryllium dust and fume ().Exposed workers can develop beryllium sensitization (BeS), a beryllium-specific, cell-mediated immune response, which is measured by the beryllium lymphocyte proliferation test (BeLPT) (2–5).Once workers develop BeS, they may subsequently develop CBD, a diffuse lung disease ...

BERYLLIUM REGISTRY CASES ACUTE CHRONIC Male Female 227 20 191191 Total Dead 247 (39%) 15 (6%) 382(61%) 121 (31%) XSr9' BERYLLIUM DISEASE 155 Acute Beryllium Poisoning.arly case reports from Germany1 and later from the United States6 contain …

Abstract. The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6 that are important in normal immune function. Susceptibility to chronic beryllium disease, a granulomatous lung disease that appears in workers exposed to beryllium, is modified by genetic variants of the HLA-DP subregion. Evaluation of HLA-DPB1 sequence motifs in current and former beryllium ...

(10) In their efforts to prevent OSHA and EPA from promulgating protective regulations limiting human exposure to beryllium, they took every opportunity to "manufacture uncertainty" about the science documenting the fact that exposure to beryllium caused lung cancer and a debilitating and usually fatal disease called chronic beryllium disease (CBD), or berylliosis.

Beryllium metal, first discovered in France in 1798, has proved to be of great value to the aerospace, nuclear, electronics, and computer industries. Its light weight, stability, considerable hardness, lack of magnetic qualities, and electrical and thermal conductivity properties make beryllium an ideal substance for various “high technology” applications.1 However, over 50 years ago, it ...

16-10-2020· Beryllium disease differs from other environmental lung diseases in that at low levels of exposure, lung problems seem to occur only in people who are sensitive to beryllium—about 2 to 6% of those who come in contact with it.

PDF | On Oct 1, 1994, Keith C. Meyer published Beryllium and Lung Disease | Find, read and cite all the research you need on ResearchGate

17-10-2020· Nagaoka K, et al. Significant improvement from chronic beryllium disease following corticosteroid pulse therapy. Ind Health. 2006;44:296-301. Fontenot AP, Maier LA. Genetic susceptibility and immune-mediated destruction in beryllium-induced disease. Trends Immunol. 2005;26:543-9. Culver DA and Dweik RA. Chronic beryllium disease.

01-12-2019· The number of workers exposed to beryllium has been estimated at 1 million in the US, although no accurate figure exists for the US or globally. The prevalence of BeS in those exposed ranges from 1 - 20%. Chronic beryllium disease (CBD) among those with BeS ranges from 15-100%.

BERYLLIUM REGISTRY CASES ACUTE CHRONIC Male Female 227 20 191191 Total Dead 247 (39%) 15 (6%) 382(61%) 121 (31%) XSr9' BERYLLIUM DISEASE 155 Acute Beryllium Poisoning.arly case reports from Germany1 and later from the United States6 contain …

15-10-2012· Chronic beryllium disease (CBD) is an immunologic lung disease caused by inhalation of beryllium dust and fume ().Exposed workers can develop beryllium sensitization (BeS), a beryllium-specific, cell-mediated immune response, which is measured by the beryllium lymphocyte proliferation test (BeLPT) (2–5).Once workers develop BeS, they may subsequently develop CBD, a diffuse lung disease ...

Beryllium exposure remains an ongoing occupational health concern for workers worldwide. Since the initial Occupational Safety and Health Administration (OSHA) ruling on a permissible exposure limit (PEL) for beryllium in 1971, our understanding of the risks of beryllium sensitization and chronic beryllium disease has evolved significantly. A new OSHA ruling released in early 2017 and ...

01-01-2001· Berylliosis is an environmental chronic inflammatory disorder of the lung caused by inhalation of insoluble beryllium (Be) dusts and characterized by …

PDF | On Oct 1, 1994, Keith C. Meyer published Beryllium and Lung Disease | Find, read and cite all the research you need on ResearchGate

Chronic beryllium disease (CBD) is a disease that primarily affects the lungs, causing inflammation, characteristic scars called granulomas and, in more severe cases, scarring called fibrosis. CBD is immune-mediated, meaning that CBD can develop only in individuals who have developed an immune response or “allergy” to beryllium metal, ceramic or alloy, termed beryllium sensitization (BeS).

Chronic beryllium disease results from beryllium exposure in the workplace and is characterized by CD4+ T cell-mediated inflammation in the lung. Susceptibility to this disease is associated with particular HLA-DP alleles. We isolated beryllium-specific T cell lines from the lungs of affected patients. These CD4+ T cell lines specifically responded to beryllium in culture in the presence of ...

17-10-2020· Nagaoka K, et al. Significant improvement from chronic beryllium disease following corticosteroid pulse therapy. Ind Health. 2006;44:296-301. Fontenot AP, Maier LA. Genetic susceptibility and immune-mediated destruction in beryllium-induced disease. Trends Immunol. 2005;26:543-9. Culver DA and Dweik RA. Chronic beryllium disease.

An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease. Am J Respir Crit Care Med. 2014;190:e34–59. Article